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OBJECTIVE: There is concern that the coronavirus disease (COVID-19) vaccine may trigger or worsen autoimmune diseases. The objective of this study was to determine the impacts of COVID-19 vaccination on symptom severity in patients with myasthenia gravis (MG). METHODS: A total of 106 enrolled patients with MG who were vaccinated against COVID-19 were followed up, and a questionnaire was used to document in detail the exacerbation of muscle weakness after vaccination and all other uncomfortable reactions after vaccination. Demographic, clinical characteristics, medication, and vaccination data were collected by follow-up interview. The main observation outcome was whether the MG symptoms of patients were exacerbated. The definition of exacerbation is according to the subjective feeling of the patient or a 2-point increase in daily life myasthenia gravis activity score relative to before vaccination, within 30 days after vaccination. RESULTS: Of 106 enrolled patients [median age (SD) 41.0 years, 38 (35.8%) men, 53 (50.0%) with generalized MG, 74 (69.8%) positive for acetylcholine receptor antibody, and 21 (19.8%) with accompanying thymoma], muscle weakness symptoms were stable in 102 (96.2%) patients before vaccine inoculation. Muscle weakness worsened in 10 (9.4%) people after vaccination, of which 8 patients reported slight symptom worsening that resolved quickly (within a few days). Two (1.9%) of patients showed serious symptom aggravation that required hospitalization. CONCLUSION: Our results suggest that inactivated virus vaccines against COVID-19 may be safe for patients with MG whose condition is stable. Patients with generalized MG may be more likely to develop increased muscle weakness after vaccination.
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COVID-19 Vaccines , COVID-19 , Myasthenia Gravis , Thymus Neoplasms , Adult , Female , Humans , Male , COVID-19/prevention & control , COVID-19/complications , COVID-19 Vaccines/adverse effects , Muscle Weakness , Myasthenia Gravis/complications , Thymus Neoplasms/complications , Vaccination/adverse effectsABSTRACT
The Moderate Resolution Imaging Spectroradiometer (MODIS) 1 km aerosol product based on the Multi-Angle Implementation of Atmospheric Correction (MAIAC) algorithm has great potential in understanding the interaction between human activities and the atmospheric environment. In this paper, the MODIS 1 km aerosol product over China during the Coronavirus Disease 2019 (COVID-19) pandemic was validated against with the ground measured data collected from the Aerosol Robotic Network (AERONET). The result shows a good agreement between the two datasets. The spatiotemporal analyses of three selected regions, which are Beijing-Tianjin-Hebei, Hubei and Guangdong-Hong Kong-Macao, indicate that the COVID-19 pandemic has a significant impact on human activities and aerosol loadings.
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Satellite remote sensing has advantages in monitoring environmental changes during the global pandemics such as the Severe Acute Respiratory Syndrome Coronavirus (SARS) and the Corona Virus Disease 2019 (COVID-19). In this paper, the variations of atmospheric environment during SARS and COVID-19 pandemics were calculated and analyzed based on the Moderate Resolution Imaging Spectroradiometer (MODIS) Atmosphere Monthly Global Product. Preliminary results show that: (1) aerosol optical depth is most affected by the pandemics, especially the duration and prevention and control measures;(2) the correlations between the variables of aerosol optical depth, cloud fraction, total column ozone and precipitable water vapor were not very strong during the two pandemics.
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The Coronavirus Disease 2019 (COVID-19) pandemic, which has lasted for more than two years, has had a huge impact on human health and the global economy, as well as the ecological environment. In this study, the variations of atmospheric environment over China from 2019 to 2020 were calculated and analyzed based on the measured total columns of ozone (O-3), sulfur dioxide (SO2), nitrogen dioxide (NO2) and aerosol optical depth (AOD) from the Ozone Monitoring Instrument (OMI) aboard NASA's Aura satellite. The study shows the impact of the epidemic prevention and control measures and the resumption of work and production on atmospheric environment, and demonstrates that satellite remote sensing can play an important role in the monitoring of the COVID-19 pandemic, especially its impact on atmospheric environment.
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As COVID-19 and other infectious diseases continue to spread globally, removing airborne pathogens from confined spaces such as buildings, transportation carriers, and stations is becoming increasingly crucial to curbing transmission and reducing human infection rates. Bioaerosols can act as vectors or media that could store and transport air pollutants and pathogens. To mitigate the adverse effects of bioaerosols and effectively control epidemics, this work reviews the current state-of-the-art air purification processes and technologies available on the market or demonstrated in laboratory and industrial settings, including ozone oxidation, UV disinfection, and photocatalysis. These reactive air purification processes can be used in conjunction with adsorption or filtration-based systems to enhance disinfection besides the physical capture of particulates or the removal of volatile organic compounds (VOCs). This review aims to provide a concise yet comprehensive overview of various reactive air purification technologies. Their principles, applications, and limitations are briefly discussed to provide insight and guidelines for further development of new air purification processes to address emerging airborne contaminant issues. © 2023 American Chemical Society.
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The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However, air quality expressed by the air quality index (AQI) did not improve in Shanghai, China, during the COVID-19 outbreak in the spring of 2022. To better understand the reason, we investigated the variations of nitrogen dioxide (NO2), ozone (O3), PM2.5 (particular matter with an aerodynamic diameter of less than 2.5 μm), and PM10 (particular matter with an aerodynamic diameter of less than 10 μm) by using in situ and satellite measurements from 1 March to 31 June 2022 (pre-, full-, partial-, and post-lockdown periods). The results show that the benefit of the significantly decreased ground-level PM2.5, PM10, and NO2 was offset by amplified O3 pollution, therefore leading to the increased AQI. According to the backward trajectory analyses and multiple linear regression (MLR) model, the anthropogenic emissions dominated the observed changes in air pollutants during the full-lockdown period relative to previous years (2019–2021), whereas the long-range transport and local meteorological parameters (temperature, air pressure, wind speed, relative humidity, and precipitation) influenced little. We further identified the chemical mechanism that caused the increase in O3 concentration. The amplified O3 pollution during the full-lockdown period was caused by the reduction in anthropogenic nitrogen oxides (NOx) under a VOC-limited regime and high background O3 concentrations owing to seasonal variations. In addition, we found that in the downtown area, ground-level PM2.5, PM10, and NO2 more sensitively responded to the changes in lockdown measures than they did in the suburbs. These findings provide new insights into the impact of emission control restrictions on air quality and have implications for air pollution control in the future. © 2023 by the authors.
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The recent COVID-19 pandemic reveals the vulnerability of global supply chains: the unforeseen supply crunches and unpredictable variability in customer demands lead to catastrophic disruption to production planning and management, causing wild swings in productivity for most manufacturing systems. Therefore, a smart and resilient manufacturing system (S & RMS) is promised to withstand such unexpected perturbations and adjust promptly to mitigate their impacts on the system's stability. However, modeling the system's resilience to the impacts of disruptive events has not been fully addressed. We investigate a generalized polynomial chaos (gPC) expansion-based discrete-event dynamic system (DEDS) model to capture uncertainties and irregularly disruptive events for manufacturing systems. The analytic approach allows a real-time optimization for production planning to mitigate the impacts of intermittent disruptive events (e.g., supply shortages) and enhance the system's resilience. The case study on a hybrid bearing manufacturing workshop suggests that the proposed approach allows a timely intervention in production planning to significantly reduce the downtime (around one-fifth of the downtime compared to the one without controls) while guaranteeing maximum productivity under the system perturbations and uncertainties.
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This article examines offshore doctoral students' challenges and opportunities to negotiate their doctoral identity development during the COVID-19 pandemic. This study draws on collaborative autoethnographic texts from the authors' diaries and a reflective discussion to understand how two offshore doctoral students negotiated their development of doctoral identity facing the pandemic. Informed by a conceptualisation of doctoral identity and distance, we explore challenges and opportunities. Results indicate that staying offshore can bring identity anxiety and a diluted sense of belonging to doctoral students, but they can control their identity by establishing caring relationships among themselves and with others. The conclusion suggests the importance of strengthening doctoral identity in a reflective and caring way to mediate COVID-19's impact.
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Aim To determine the antiviral and anti-inflammatory effects of the recommended prescription for COVID-2019-lung-spleen qi deficiency(4-1)against in vitro infection of SARS-CoV-2 and common coronaviruses.Methods The main chemical substances of 4-1 were analyzed by LC-MS.The toxicity and antiviral effects of of 4-1 were detected by MTT and by CPE assay, respectively.The viral loads in cell supernatant and the expression of inflammatory factors induced by viral infection were determined by qRT-PCR.Results The recommended prescription 4-1 contained 94 chemical compounds, including flavonoids, steroids, sesquiterpenoids, and so on.The range of selection indexes for SARS-CoV-2 and common coronaviruses was 8.44+/-0.49~52.26+/-2.3.This prescription could inhibit the proliferation of SARS-CoV-2, the expression of ACE2 and S mRNA, and down regulate IL-1alpha and CCL-5/RANTES at 10, 5, and 2.5 g*L-1 doses.Further, at doses of 20, 10 and 5 g*L-1, it could inhibit the proliferation of three common coronaviruses and suppress the overexpression of IL-6, CXCL-8/IL-8, CXCL-10/IP-10, TNF-alpha, IFN-alpha, CCL-2/MCP-1, MIG and CCL-5/RANTES induced by OC43/229E infection.The inhibitory effects were dose-dependent.Conclusions The prescription 4-1 has antiviral and anti-inflammation effects against multiple coronaviruses.This study provides the research basis for the treatment of common respiratory viral infections and emerging infectious diseases such as COVID-19 by using traditional Chinese medicine. Copyright © 2022 Publication Centre of Anhui Medical University. All rights reserved.
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The pandemic of COVID-19 has led to a surge increase in the production of masks. Due to the rapid propagation of COVID-19 and the long survival time of plastic surfaces, a large number of masks are discharged into the environment without treatment. In this paper, the release of microplastics (MPs) in nature was simulated by using mask samples irradiated by ultraviolet (UV) light. After 28 days of ultraviolet radiation, part of the main chain of the mask was broken and a large number of transparent MPs fell off. The longer the UV irradiation time, the larger the proportion of small particle MPs. The middle layer of surgical mask is the most difficult to release MPs due to charge treatment, and N95 mask is the most difficult to degrade the inner material. © 2022, HARD Publishing Company. All rights reserved.
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Introduction: Immunosuppressed individuals are at higher risk for COVID-19 and resulting complications, yet robust data in patients with Inflammatory Bowel Disease (IBD) are lacking. We evaluated the risk of COVID-19-related hospitalization and severe sequelae in a large, population-based U.S. cohort of patients with IBD. Methods: We conducted a retrospective cohort study utilizing insurance claims data from two large U.S. health plans (Anthem and Humana). Cohort follow-up began on 1 March 2020, the beginning of the COVID-19 pandemic in the US. We included IBD patients identified by two diagnosis codes for Crohn's disease (CD) or ulcerative colitis (UC) or one diagnosis code plus a treatment code for an IBD-specific medication in the six months prior to cohort entry. Use of IBD medications was ascertained in the 90 days prior to cohort entry. Study outcomes included COVID-19 hospitalization, mechanical ventilation, and inpatient death. Patients were followed until outcome of interest, death, disenrollment, or end of the study period. We described the occurrence of COVID-19 outcomes according to IBD treatment status ascertained prior to cohort entry. Results: The study population included 102,989 patients (48,728 CD, 47,592 UC) with a mean age of 53 years;55% were female. Overall, 412 (0.4%) patients were hospitalized for COVID-19. Individuals treated with systemic corticosteroids were more likely to be hospitalized than those treated with any other non-steroid medication (0.6% vs 0.3%, p=<.0001). Among patients not treated with corticosteroids, patients receiving anti-TNF were less likely to be hospitalized than those treated with other medication classes (0.2% vs 0.5%, p=<.0001) or no medications (0.5%, p=<.0001). Older age was associated with increased incidence of hospitalization for COVID-19. Overall, 71 patients (0.07%) required mechanical ventilation and 52 (0.05%) died at the hospital due to COVID-19 or resulting complications. The proportion of patients requiring mechanical ventilation or dying was higher amongst users of corticosteroids versus those treated with any other non-steroid medication (1.9% vs 0.05%, p=<.0001 and 0.1% vs 0.04%, p=0.0015) respectively). Associations between corticosteroid use all outcomes were similar across age groups. Conclusion: Among patients with IBD, those treated with systemic corticosteroids had more frequent hospitalization, mechanical ventilation, and death from COVID-19 as compared to patients on other treatments or no treatment at all. Anti-TNF therapy was associated with a decreased occurrence of hospitalization. This finding reinforces previous guidance to taper and/or discontinue corticosteroids to reduce the risk of infections, including COVID-19. Use of steroid-sparing maintenance treatments such as anti-TNF agents appears to be safe.
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Due to the Coronavirus Disease (COVID-19) pandemic, the human activities in China and even in the world were reduced in 2020, which also caused the variation of the atmospheric environment, especially atmospheric aerosol emissions. In this paper, the MODIS level-3 gridded atmosphere monthly global joint product in 2019 and 2020 were collected and processed. After preliminary analysis, we found that MODIS annual aerosol optical depth (AOD) over China in 2020 is generally lower than in 2019. In some regions such as Beijing-Tianjin-Hebei and Yangtze River Delta, AOD values dropped the most in February. However, in some months and regions, AOD in 2020 is even higher than in 2019. More studies are still ongoing. © 2021 IEEE.
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Affected by the Coronavirus Disease (COVID-19) pandemic, almost all students in China have to study online at home from February to June, 2020. In this paper, we discussed the forms of online courses and took Jiangsu Normal University as an example to introduce the online courses of remote sensing in China. The results of the satisfaction survey show that more than 90% of the respondents agree with online courses and believe that online courses can at least meet basic learning needs in the age of COVID-19, and more than 60% of respondents claimed that they had met or exceeded their learning expectations. The major advantages of online course include reducing the gathering of people and thus the risk of infection. However, there are still some problems with online courses, and we hope that these problems can be solved well in the future. © 2021 IEEE
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Artemisinin, extracted from the traditional Chinese medicine Artemisia annua Linn., has a powerful antimalarial effect. With further research, artemisinin and its derivatives have been found to have antiviral effects against a variety of viruses from different viral families, including Herpesviridae, Flaviridae, and Coronaviraceae, and can inhibit virus-induced inflammatory responses. The possible antiviral mechanisms include alkylation of DNA binding domain of NF-κB P65 subunit, inhibition of plasmidic nuclear transport of NF-κB p65, production of reactive oxygen species or activation of carbon center free radicals to regulate host Keap1/Nrf2/ARE pathway to inhibit viral replication. The inflammatory response was alleviated by inhibiting the activation of NF-κB and ERK pathways induced by the virus. This paper reviews the possible antiviral mechanism of artemisinin and its derivatives to provide reference for artemisinin to fight new viruses and promote new use of old drugs. © 2022 by the authors.
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Aiming at the problem of long queuing temperature and low efficiency during the period of COVID-19, an intelligent temperature measurement and access control system is designed. It is widely used in enterprises, institutions, scenic spots, commercial areas and other places with large traffic volume. The main control system adopts stm32f407zgt6 embedded chip, hc-sr501 human body infrared sensor is sensitive to human body proximity, and starts the temperature measurement system. Using hc-sr04 ultrasonic sensor to measure people's height and adjust the height of mlx9064esf temperature probe, the system has the characteristics of efficient real-time temperature monitoring, and improves the detection efficiency in places with large flow of people. The experimental results show that the system has good practical application effect. © 2022 IEEE
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OBJECTIVE: This study aimed to systematically clarify attitudes and influencing factors of the public toward COVID-19 vaccination for children or adolescents. STUDY DESIGN: This was a scoping review. METHODS: This scoping review screened, included, sorted, and analyzed relevant studies on COVID-19 vaccination for children or adolescents before December 31, 2021, in databases, including PubMed, Elsevier, Web of Science, Cochrane Library, and Wiley. RESULTS: A total of 34 studies were included. The results showed that the public's acceptance rate toward COVID-19 vaccination for children or adolescents ranged from 4.9% (southeast Nigerian mothers) to 91% (Brazilian parents). Parents' or adolescents' age, gender, education level, and cognition and behavior characteristics for the vaccines were the central factors affecting vaccination. The vaccine's safety, effectiveness, and potential side-effects were the main reasons affecting vaccination. CONCLUSIONS: Realizing current public attitudes of COVID-19 vaccination for adolescents or children can effectively develop intervention measures and control the pandemic as soon as possible through herd immunity.
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COVID-19 , Vaccines , Adolescent , Attitude , COVID-19/prevention & control , COVID-19 Vaccines/therapeutic use , Child , Female , Humans , Parents , VaccinationABSTRACT
Detecting the crisis of supply chain management is an important subject for the sustainable management of e-commerce. The purpose of this study was to explore the application of Q-technique to the detection of supply chain crises in the imported food industry under the influence of COVID-19. Literature analysis, expert consultation, and Q-technique methods were adopted. We used an expert consultation and questionnaire survey combined with Q-technique using the imported food industry in Taiwan as an example. Fifteen business owners were interviewed to identify priorities for supply chain crises, and 137 questionnaires were collected to determine the strength of each item. By investigating suppliers, distributors, wholesalers, platform operators, online sellers, and logistics operators, this study obtained the priority of supply chain crisis items and the strength of factors for each item. The results show that Q-technique can effectively detect the crisis of cross-border supply chain management, clarifying import food industry e-commerce supply chain crisis items and determining their priority and strength, to help enterprises make emergency decisions regarding supply chain operation, and they can also be used as a reference for enterprises to respond to the crisis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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Objective: To understand patient experiences with FL disease and treatment through SML. Method: Social media data were extracted between February 2019 and July 2020 using “Follicular Lymphoma” and related keywords via Social Studio®, an online aggregator tool for social media posts. English as well as local language posts were extracted from five countries including United States (US), Canada, United Kingdom (UK), Germany and France. Patient conversations were identified, synthesized, mapped, and analyzed to understand different concerns. Results: 487 patient posts discussing 1324 topics of conversation were identified. In most countries, top discussed topics included patient concerns such as quality of life (QoL) changes, and disease and/or treatment management. Multiple patient concerns (n=554) were observed across all geographies: impact on QoL (198), curability (73), fear of relapse/progression (64), disease/treatment information need (50), lack of emotional support (43), FL transformation to diffuse large B-cell lymphoma (42), and cost of treatment (30) were notable concerns. To assess QoL impact, patient conversations (198) were mapped to the statements in the Functional Assessment of Cancer Therapy – Lymphoma questionnaire (FACT-Lym). Pain and lack of energy (57), swollen nodes/lumps (47), and side effects of treatment (31) had impacted physical wellbeing, while support from family/friends (41) helped patients cope emotionally. A few patients (18) said that they were able to return to work after treatment. As for inter-country differences, conversations were mostly from the US (43%) and UK (20%);male patients in Germany were more active social media participants than female patients, which was different from other four countries;only patients in the UK had expressed concerns about COVID-19 impact. Conclusion: Insights from international SML research indicated concerns related to disease- and/or treatment-related impact on QoL and interest about potential cure for the disease.